Protective Effects of Several Plant Polyphenols against Chromosomal Damage Induced in Vivo by X-rays. Comparative Study versus Diosmin and Rutin* Xa0101760
نویسندگان
چکیده
Protective effects of grape (Vitis vinifera) seed (GSE), Citrus spp. fruits (CE) and olive {Olea europaea L.) leaf (OL) extracts, the flavonoids diosmin and rutin, widely used as pharmaceuticals, and dimethylsulphoxide (DMSO) against chromosomal damage induced by X-rays were determined by using the micronucleus test for anticlastogenic activity. The reduction of the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in bone marrow of mouse exposed to X-rays was examined. The most effective compounds were, in order: GSE « CE > rutin « DMSO « OL > diosmin. These results suggest a correlation between the antioxidant and anticlastogenic activity of these polyphenolic extracts.
منابع مشابه
Radioprotective Effects of Flavonoids against to Chromosomal Damage: Relation between the Structure and Activity
The polyphenolic distribution of Vitis vinifera seeds (GSE), Citrus spp. fruits (CE) and Olea europaea L. leaves (OL) extracts were characterized and quantified by HPLC methods. Radioprotective effects of these extracts and the reference flavonoids diosmin and rutin, widely used as pharmaceuticals, were determined by using the micronucleus test for anticlastogenic activity, evaluating the reduc...
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